The meditrol FOB cartridge test is a visual,
immuno-chromatographic rapid test for qualitative detection of
human hemoglobin in stool samples (fecal occult blood = FOB).
for qualitative detection of human hemoglobin in the stool
package includes 15 test cartridges, sampling tubes and
Intended only for professional in vitro use.
Designed to deliver indications of disease in the large
instestine, such as colon cancer and larger hemorrhoids.
The immunological meditrol FOB rapid test's immuno-chromatographic
method is based on recognizing human hemoglobin exclusively through
a specific antibody reaction. The hemoglobin contained in the stool
sample reacts with specific monoclonal antibodies that are bound to
gold particles. This complex spreads over the membrane and reaches
the test strips (T) on which resides the anti-hemoglobin. In a
positive result, the hemoglobin molecules loaded with antibodies
and their gold markers are bound to the test strips (T) and become
visible as a pink coloration. In a negative, no hemoglobin molecule
complex can bind to the test strip (T) and so there is no
coloration. A control band (C) guarantees through its pink
coloration that the sample deposit and the sample migration
occurred correctly and that the test is valid.
Colon cancer risk
Colon cancer is one of the most frequently diagnosed cancer types
and one of the most frequent causes of cancer deaths (Lieberman,
1994; MMWP, 1995). By testing occult blood in stools, colon cancer
can be recognized early on and the mortality rate reduced. (Dam et.
al., 1995; Miller, 1995; and Lang, 1996). Previously, tests for
occult blood relied on the Guajac method, requiring a special diet
to avoid false positives and false negatives. The highly specific
meditrol FOB therefore was developed for the purpose of indicating
human hemoglobin in stool samples. The test is based on an
immunochemical method that improves detection of disease in the
large intestine over the classic Guajac method through higher
sensitivity and specificity.(Frommer et. al., 1988; St. John et.